P Potency and selectivity of GSK 1325831 A , a small molecule ghrelin receptor agonist

نویسندگان

  • Jill Darton
  • William Unsworth
  • Julia Smith
  • Karen Townson
  • Alan Wheeldon
  • Wendy Winchester
  • Jason Witherington
  • Gareth Sanger
  • Kevin Lee
چکیده

Ghrelin has role in modulating food intake and gastrointestinal motility in several species (Korbonits et.al., 2004). Since exogenous administration of ghrelin has been shown to accelerate gastric emptying in rats and humans (Carpino et. al., 2002), the ghrelin receptor has become a target for pharmaceutical intervention. The aim of these studies was to determine the efficacy of GSK1325831A (N-[6-[cis-3,5-Dimethyl-1-piperazinyl]-3-(methyloxy)-2-pyridinyl]3fluoro-4-(5-methyl-2-furanyl)benzenesulfonamide hydrochloride (E3)), a small molecule ghrelin receptor agonist to increase gastric emptying

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تاریخ انتشار 2009